Hypothyroidism is a disorder where the thyroid gland does not produce enough thyroid hormone. It can be associated with a loss of brow hair along the lateral one third of the eyebrow, sometimes referred to as Queen Anne’s sign. The nickname Queen Anne’s sign originates from a portrait of the Queen of Denmark in which she is shown with loss of hair along her brows. Besides addressing any underlying medical conditions, fixing eyebrow hair loss is most often done with off-label use of Latisse. Designed for eyelash improvement, Latisse has been shown to help brow hair become thicker and fuller.